We are committed to partnering with foundations and the medical community dedicated to bicuspid aortic valve disease (BAVD) so that significant advancements are made to better understand and prevent premature deaths arising from this condition. It is estimated that as many as one out of every 50 people (one child every 12 seconds worldwide) is born with a bicuspid aortic valve, making it the most common congenital heart defect. A bicuspid aortic valve occurs when the valve is formed with only two leaflets, or cusps, instead of three. These cusps work together as a one-way gate allowing the blood to flow from the left ventricle into the aorta. A defective valve with only two cusps instead of three can result in aortic stenosis (when the cusps do not open all the way, hindering blood flow from the heart) and/or aortic insufficiency (when the blood leaks backward toward the heart). Because the heart has to work much harder to pump the blood through the narrowed valve and/or re-pump regurgitated blood back through the valve, a number of potentially life-threatening complications can arise.